Authors' objectives: To assess the efficacy and safety of autologous peripheral blood stem cells for articular cartilage regeneration.

Authors' recommendations: There were two studies on peripheral blood stem cells identified, a randomised controlled trial (in-press) and a case series. Unpublished long term non-comparative data on efficacy and safety were also obtained. Three studies on intra-articular mesenchymal stem cells were included as well. The usage of the new technique that "is the combination of the microfracture surgery or subchondral drilling, and the administration of hyaluronic acid and peripheral blood stem cells" is an innovation introduced by Dr Saw et al. Limited good level of evidence showed that intra-articular injection of peripheral blood stem cells in combination with hyaluronic acid (HA) resulted in improvement of the quality of articular cartilage repair when compared to treatment with HA alone as observed from the MRI and histologic findings. The evidence showed that there was no serious adverse event or complications reported when applying this procedure.

Project Status: Completed

Year Published: 2013

URL for published report: http://www.moh.gov.my/index.php/database_stores/store_view_page/30/195

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Malaysia

Organisation Name: Malaysian Health Technology Assessment

Contact Address: Malaysian Health Technology Assessment Section, Ministry of Health Malaysia, Federal Government Administrative Centre, Level 4, Block E1, Parcel E, 62590 Putrajaya Malaysia Tel: +603 8883 1229

Contact Name: htamalaysia@moh.gov.my

Contact Email: htamalaysia@moh.gov.my

Copyright: Malaysian Health Technology Assessment (MaHTAS)