Authors' objectives: To assess the efficacy, safety and cost-effectiveness of platelet rich plasma for the treatment of osteoarthritis.

Authors' recommendations: Two systematic reviews, two randomised controlled trials and a non-randomised controlled trial were included in this review. There was insufficient but good level of evidence to support the effectiveness of PRP for the treatment of osteoarthritis. The longest outcome data available was only for 24 months in a study and revealed that the median beneficial results was nine months. Most of the studies available were case series. Studies that have comparisons, used hyaluronic acid as control. In certain countries such as the United Kingdom, intra-articular hyaluronic acid injections are not recommended for the treatment of osteoarthritis. The short term evidence showed that PRP may be beneficial for young (<50 years old) patients with early OA and not overweight or obese. However, the evidence is limited. In terms of safety, no major complications were reported in patients treated with PRP.

Project Status: Completed

Year Published: 2013

URL for published report: http://www.moh.gov.my/index.php/database_stores/store_view_page/30/214

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Malaysia

Organisation Name: Malaysian Health Technology Assessment

Contact Address: Malaysian Health Technology Assessment Section, Ministry of Health Malaysia, Federal Government Administrative Centre, Level 4, Block E1, Parcel E, 62590 Putrajaya Malaysia Tel: +603 8883 1229

Contact Name: htamalaysia@moh.gov.my

Contact Email: htamalaysia@moh.gov.my

Copyright: Malaysian Health Technology Assessment (MaHTAS)