Treatments for constipation: a review of systematic reviews

Record ID 32016000195
Authors' recommendations: In adults and children with chronic constipation, polyethylene glycol (PEG), increased the frequency of stools relative to placebo, lactulose and milk of magnesia. Stool frequency was also increased in adults treated with prucalopride versus placebo. Laxatives and prucalopride may increase the risk of diarrhea. No conclusions can be drawn with regards to stool softeners or bulking agents. The available studies were generally of lower methodological quality with limited data available for many treatment comparisons or for safety.
Project Status: Completed
Year Published: 2014
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Canada
MeSH Terms
  • Constipation
  • Dietary Fiber
  • Ileus
  • Laxatives
  • Serotonin 5-HT4 Receptor Agonists
Organisation Name: Canadian Agency for Drugs and Technologies in Health
Contact Address: 600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553; Fax: +1 613 226 5392;
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Copyright: Canadian Agency for Drugs and Technologies in Health (CADTH)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.