Authors' recommendations: OHTAC members acknowledged that there was uncertainty in the evidence that islet transplantation improved secondary complications of diabetes and quality of life. However, OHTAC also recognized that patients being treated with islet transplantation had a very complicated form of diabetes and that a substantial proportion of these patients achieved insulin independence for at least several years. For the patients who did not achieve insulin independence, or in later years lost insulin independence, other outcomes for glycemic control were generally improved. For example, many patients required less insulin than they did before transplantation, and had better blood glucose control. The clinical benefits of islet transplantation were considered, along with the adverse events that may occur as a result of the procedure and the lifelong immunosuppression regimens that are required. OHTAC also noted that the number of patients eligible for this treatment would be small; hence, the total budget impact would be limited.

Project Status: Completed

Year Published: 2015

URL for published report: http://www.hqontario.ca/Portals/0/Documents/eds/ohtas/recommendation-pancreas-islet-transplantation-1509-en.pdf

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Canada

Organisation Name: Health Quality Ontario

Contact Address: Evidence Development and Standards, Health Quality Ontario, 130 Bloor Street West, 10th floor, Toronto, Ontario Canada M5S 1N5

Contact Name: EDSinfo@hqontario.ca

Contact Email: OH-HQO_hta-reg@ontariohealth.ca

Copyright: Health Quality Ontario (HQO)