Pancreas islet transplantation for patients with type 1 diabetes mellitus: a clinical evidence review

Health Quality Ontario
Record ID 32015001201
English
Authors' recommendations: Islet transplantation offers an alternative for patients with type 1 diabetes who have brittle diabetes with difficult-to-control blood glucose levels or hypoglycemic unawareness despite optimal insulin therapy. Treatment depends on patient eligibility and is influenced by donor islet availability, technical limitations of the procedure, and immunosuppression protocols. In non-uremic patients, compared with (a) status prior to islet transplantation or (b) intensive insulin therapy, islet transplantation alone generally: • Improves glycemic control (GRADE: low to high) • Improves secondary complications for diabetes (GRADE: very low to low) • Increases procedure-related and immunosuppression-related adverse events (GRADE: low) • Improves health-related quality of life (GRADE: very low) In uremic patients, compared with (a) status prior to islet transplantation or (b) intensive insulin therapy, simultaneous islet-kidney transplantation and islet-after-kidney transplantation generally: • Improve glycemic control (GRADE: low to high) • Improve secondary complications for diabetes (GRADE: low) • Increase procedure-related and immunosuppression-related adverse events (GRADE: low) • Improve health-related quality of life (GRADE: very low) Additional long-term comparative studies are required for a better understanding of the continuing effects of transplanted islets and the immunosuppression protocols used. Ontario
Details
Project Status: Completed
Year Published: 2015
URL for published report: http://www.hqontario.ca/Portals/0/Documents/eds/ohtas/eba-pancreas-islet-transplantation-1509-en.pdf
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Canada
MeSH Terms
  • Islets of Langerhans
  • Diabetes Mellitus, Type 1
  • Islets of Langerhans Transplantation
  • Pancreas Transplantation
Contact
Organisation Name: Health Quality Ontario
Contact Address: Evidence Development and Standards, Health Quality Ontario, 130 Bloor Street West, 10th floor, Toronto, Ontario Canada M5S 1N5
Contact Name: EDSinfo@hqontario.ca
Contact Email: OH-HQO_hta-reg@ontariohealth.ca
Copyright: Health Quality Ontario (HQO)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.