Authors' objectives: To assess the available evidence on the efficacy, safety and coverage related aspects regarding the use of deep brain stimulation in Parkinson's disease.

Authors' recommendations: There is high methodological quality evidence supporting the use of deep brain stimulation for the treatment of advance Parkinson's disease with poor symptom control with adequate medical treatment. In addition, it showed the UPDRS scale results, do not differ depending on the site of stimulation and that the STN stimulation would allow using a lower L-dopa dose. Evidence of moderate methodological quality regarding the effect of the stimulation site showed there is no effect on swallowing disorders and it was non-conclusive about depression. The clinical practice guidelines and coverage policies found agree to support deep brain stimulation use for advance Parkinson's disease, with poor symptom control with adequate medical treatment. Being over 70 years old is a relative contraindication and contraindication is absolute over 85 years old.

Project Status: Completed

Year Published: 2015

URL for published report: http://www.iecs.org.ar/publicacion/?id=5235

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Argentina

Organisation Name: Institute for Clinical Effectiveness and Health Policy

Contact Address: Dr. Emilio Ravignani 2024, Buenos Aires - Argentina, C1414 CABA

Contact Name: info@iecs.org.ar

Contact Email: info@iecs.org.ar

Copyright: Institute for Clinical Effectiveness and Health Policy (IECS)