A health technology assessment of transient elastography in liver disease
Steadman R, Leggett L, Lorenzetti D, Noseworthy T, Rose S, Sutherland L, Clement F
Record ID 32015001082
English
Authors' recommendations:
TE is an accurate method for liver disease diagnosis in patients with significant or severe fibrosis
and cirrhosis. The diagnostic accuracy is similar across all the disease subgroups considered.
However, its effectiveness decreased as the severity of fibrosis decreased. Compared to LB, TE
is less expensive, but it is less effective. TE's diagnostic accuracy, calculated using the AUROC,
ranged from 0.78 to 0.96 when LB was accepted as the standard of care with a diagnostic
accuracy of 100%. LB was associated with an additional $1,427 to $7,030 per correct diagnosis
gained compared to TE. However, when the likelihood of receiving LB is greater than 78% after
undergoing TE, LB is a more economically attractive option (i.e. LB will cost the same as TE,
but LB will have an increased clinical benefit due to its diagnostic accuracy). There are a variety
of other factors that may influence the attractiveness of TE that are uncounted for in this
analysis: patient preference for a non-invasive test, fewer physician visits are required with TE,
and no pre-screening blood tests. System implementation of TE for liver disease should be
considered.
Details
Project Status:
Completed
Year Published:
2012
URL for published report:
http://www.health.alberta.ca/documents/AHTDP-ETG-UofC-STE.pdf
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Canada
MeSH Terms
- Humans
- Liver
- Elasticity Imaging Techniques
- Liver Cirrhosis
- Liver Diseases
Contact
Organisation Name:
HTA Unit, University of Calgary
Contact Address:
3rd Floor, TRW Building, University of Calgary, 3280 Hospital Dr NW, Calgary, Alberta, Canada, T2N 4Z6
Contact Name:
fclement@ucalgary.ca
Contact Email:
fclement@ucalgary.ca
Copyright:
University of Calgary
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.