Authors' recommendations: At the request of the Minister of Social Affairs and Employment, the Dutch Expert Committee on Occupational Safety (DECOS), a Committee of the Health Council of the Netherlands, derives so-called health-based calculated occupational cancer risk values (HBC-OCRVs) associated with excess mortality levels of 4 per 1,000 and 4 per 100,000 as a result of working life exposure to substances. It concerns substances which are classified by the Health Council or the European Union in category 1A or 1B, and which are considered stochastic genotoxic carcinogens. For the estimation, the Committee uses the Guideline for the calculation of occupational cancer risk values of the Health Council. In this report the Committee evaluates the possibility to establish such estimates for thiotepa. Thiotepa is administered to patients as a chemotherapeutic agent. Occupational exposure occurs in employees involved in the production, preparation and administration of this substance. In this report, the Committee concludes that thiotepa is a carcinogenic substance with a stochastic genotoxic mechanism. The Committee is of the opinion that due to a lack of adequate human and animal data, it is not possible to establish the health-based calculated occupational cancer risk values for thiotepa.

Project Status: Completed

Year Published: 2015

URL for published report: http://www.gezondheidsraad.nl/sites/default/files/201517_thiotepa_1.pdf

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Netherlands

Organisation Name: Health Council of the Netherlands Gezondheidsraad

Contact Address: Postbus 16052, 2500 BB Den Haag, The Netherlands. Tel: +31 70 340 7520;Fax: +31 70 340 7523

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Contact Email: info@gr.nl

Copyright: Health Council of the Netherlands