Study of adherence to Recombinant Growth Hormone treatment of children with a GH deficiency: contributions to treatment control and economic impact
Saz-Parkinson Z, Granados MS, Amate Blanco JM
Record ID 32015000962
English,Spanish
Authors' objectives:
The treatment for children with growth hormone deficit has notably evolved since its first uses from human cadavers (1958), until the arrival of recombinant human growth hormone (1985). This biotechnological advance has allowed an expansion in its uses due to a greater availability, as well as a greater biological safety
of this hormone and significant refinements regarding its dosage and administration frequency, with significant results in the final growth of these children. However, the existence of non-responder phenotypes, as well as the more common lack of therapeutic compliance, can pose severe limitations regarding effectiveness, with the corresponding economic impact for Health Systems, which may be mitigated by innovations in administration devices.
Authors' recommendations:
Adherence to treatment is one of the most important practical aspects to take into account in treatments such as this one, of prolonged duration and complex administration. Administration of growth hormone using an electronic device allows complete use of the total vial content. At the same time, it registers information regarding therapeutic compliance which allows: a) aiding in the optimal adjustment of treatment regimen by specialist; b) identification of patients with a non-responder phenotype.
Details
Project Status:
Completed
Year Published:
2013
URL for published report:
http://gesdoc.isciii.es/gesdoccontroller?action=download&id=06/10/2014-453f87cb91
URL for additional information:
http://gesdoc.isciii.es/gesdoccontroller?action=download&id=13/01/2014-610d57425b
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Spain
MeSH Terms
- Human Growth Hormone
- Growth Disorders
- Recombinant Proteins
- Body Height
- Economics, Medical
Contact
Organisation Name:
Agencia de Evaluacion de Tecnologias Sanitarias
Contact Address:
Instituto de Salud "Carlos III", Calle Sinesio Delgado 6, Pabellon 4, 28029 Madrid, Spain. Tel: +34 9 1 822 2005; Fax: +34 9 1 387 7841;
Contact Name:
Luis M. Sánchez Gómez
Contact Email:
luism.sanchez@isciii.es
Copyright:
Agencia de Evaluacion de Tecnologias Sanitarias (AETS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.