[Local injection therapy with bulking agents for faecal incontinence]

Ludwig Boltzmann Institut fuer Health Technology Assessment (LBI-HTA)
Record ID 32015000950
Authors' objectives: Faecal incontinence (FI) is the involuntary loss of intestinal contents. There is a passive and an acute form. FI causes considerable physical impairments for patients and massive restrictions in the quality of life. Injectable bulking agents are supposed to represent an alternative to conservative therapy options (e.g., dietary, sphincter training, biofeedback, medication). The aim of this systematic review is to evaluate the efficacy and safety of bulking agents in comparison to the standard therapy and to compare different bulking agents.
Authors' recommendations: The available (low) evidence points to the fact that patients with passive FI do not benefit more from bulking agents than from a standard therapy. Besides, the relevance of a prominent endpoint for patients (≥50 % reduction of incontinence episodes) is contested. Against this backdrop, robust RCTs and further research are needed in order to gain substantial evidence about long-term outcomes (e.g., quality of life). Currently, the inclusion into the hospital benefit catalogue is not recommended. A re-evaluation is proposed in 2018.
Project Status: Completed
Year Published: 2015
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Austria
MeSH Terms
  • Intestinal Mucosa
  • Defecation
  • Anal Canal
  • Dextrans
  • Hyaluronic Acid
  • Injections
  • Injections, Intralesional
  • Acrylic Resins
  • Biocompatible Materials
  • Collagen
  • Dimethylpolysiloxanes
  • Glucans
  • Hydrogels
  • Silicones
Organisation Name: Ludwig Boltzmann Institute for Health Technology Assessment
Contact Address: Ludwig Boltzmann Institute for fuer Health Technology Assessment (LBI-HTA), Garnisongasse 7/rechte Stiege Mezzanin (Top 20), 1090 Vienna, Austria. Tel: +43 1 236 8119 - 0 Fax: +43 1 236 8119 - 99
Contact Name: tarquin.mittermayr@aihta.at
Contact Email: office@aihta.at
Copyright: Ludwig Boltzmann Institut fuer Health Technology Assessment (LBI-HTA)
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