Subcutaneous Injection of Adalimumab Trial compared with Control (SCIATiC): a randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica

Williams N H, Jenkins A, Goulden N, Hoare Z, Hughes D A, Wood E, Foster N E, Walsh D A, Carnes D, Sparkes V, Hay E M, Isaacs J, Konstantinou K, Morrissey D, Karppinen J, Genevay S & Wilkinson C
Record ID 32015000720
English
Authors' objectives: To test whether or not injections of adalimumab plus physiotherapy are more clinically effective and cost-effective than injections of saline plus physiotherapy for patients with sciatica.
Authors' recommendations: The main failure was attributable to problems with contracts. Because of this we were not able to complete the internal pilot or to test all of the different methods for primary care recruitment we had planned. A trial of biological therapy in patients with sciatica still needs to be done, but would require a clearer contracting process, qualitative research to ensure that patients would be willing to participate, and simpler recruitment methods.
Details
Project Status: Completed
URL for project: http://www.nets.nihr.ac.uk/projects/hta/1220102
Year Published: 2017
URL for published report: https://www.journalslibrary.nihr.ac.uk/hta/hta21600/#/abstract
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England, United Kingdom
MeSH Terms
  • Adult
  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal, Humanized
  • Injections, Subcutaneous
  • Sciatica
  • Randomized Controlled Trial
  • Physical Therapy Modalities
Contact
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name: journals.library@nihr.ac.uk
Contact Email: journals.library@nihr.ac.uk
Copyright: Queen's Printer and Controller of HMSO
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