Chlorpromazine - Evaluation of the effects on reproduction, recommendation for classification

Health Council of the Netherlands
Record ID 32015000618
English
Authors' recommendations: In the present report the Health Council of the Netherlands reviewed chlorpromazine. In the Netherlands, chlorpromazine may be prescribed in the management of nausea and vomiting in case other medicines are contraindicated, in palliative sedation for the relief of delirium, dyspnoea and restlessness, and in the treatment of intractable hiccups. This report is part of a series, in which the Health Council evaluates the effects of substances on reproduction, at request of the Minister of Social Affairs and Employment. It mainly concerns substances to which man can be exposed occupationally. The Subcommittee on the Classification of Reproduction Toxic Substances of the Dutch Expert Committee on Occupational Safety of the Health Council, hereafter called the Committee, evaluates the effects on male and female fertility and on the development of the progeny. Furthermore, the Committee considers the effects of a substance on lactation and on the progeny via lactation. The Committee recommends classification according to Regulation (EC) 1272/2008 of the European Union. For chlorpromazine, these recommendations are: • for effects on fertility, the Committee recommends classifying chlorpromazine in category 1B (presumed human reproductive toxicant) and labelling with H360F (may damage fertility) • for effects on development, the Committee recommends classifying chlorpromazine in category 1B (presumed human reproductive toxicant) and labelling with H360D (may damage the unborn child) • for effects on or via lactation, the Committee recommends not labelling chlorpromazine due to a lack of appropriate data.
Details
Project Status: Completed
Year Published: 2015
URL for published report: http://www.gr.nl/sites/default/files/201514chlorpromazine.pdf
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Netherlands
MeSH Terms
  • Animals
  • Female
  • Male
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Rats
  • Rats, Inbred Strains
  • Body Weight
  • Chlorpromazine
  • Estrus
  • Fetus
  • Insemination
  • Organ Size
  • Reproduction
Contact
Organisation Name: Health Council of the Netherlands Gezondheidsraad
Contact Address: Postbus 16052, 2500 BB Den Haag, The Netherlands. Tel: +31 70 340 7520;Fax: +31 70 340 7523
Contact Name: info@gr.nl
Contact Email: info@gr.nl
Copyright: Health Council of the Netherlands
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