Dimethyl sulphate. Health-based calculated occupational cancer risk values
Health Council of the Netherlands
Record ID 32015000605
English
Authors' recommendations:
At the request of the Minister of Social Affairs and Employment, the Dutch Expert Committee on Occupational Safety (DECOS), a committee of the Health Council of the Netherlands, derives so-called health-based calculated - occupational cancer risk values (HBC-OCRVs) associated with excess cancer risk levels of 4 per 1,000 and 4 per 100,000 as a result of working life exposure to substances. It concerns substances which are classified by the Health Council or the European Union in category 1A or 1B, and which are considered stochastic genotoxic carcinogens. For the estimation, the Committee uses the Guideline for the calculation of occupational cancer risk values of the Health Council.1 In this report the Committee evaluates the possibility to establish such estimates for dimethyl sulphate. Dimethyl sulphate is used as a methylating agent in the manufacturing of dyes, perfumes, pharmaceuticals, for the separation of mineral oils, and for the analysis of automobile fluids. Also its sulphating properties are applied in the manufacturing of various products (e.g. dyes and fabric softeners, etc.).
In this report, the Committee concludes that dimethyl sulphate is a carcinogenic substance with a stochastic genotoxic mechanism. The Committee recommends dimethyl sulphate to be classified in category 1B (substance presumed to be carcinogenic to humans).
The Committee is further of the opinion that due to a lack of adequate human and animal data, it is not possible to exactly establish the health-based calculated occupational cancer risk values for dimethyl sulphate.
Details
Project Status:
Completed
Year Published:
2014
URL for published report:
http://www.gr.nl/sites/default/files/201427_dimethyl_sulphate.pdf
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Netherlands
MeSH Terms
- Adult
- Autopsy
- Chemical Industry
- Environmental Exposure
- Male
- Occupations
- Alkylating Agents
- Carcinoma
- Lung Neoplasms
- Occupational Diseases
Contact
Organisation Name:
Health Council of the Netherlands Gezondheidsraad
Contact Address:
Postbus 16052, 2500 BB Den Haag, The Netherlands. Tel: +31 70 340 7520;Fax: +31 70 340 7523
Contact Name:
info@gr.nl
Contact Email:
info@gr.nl
Copyright:
Health Council of the Netherlands
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.