Authors' recommendations: In the present report the Health Council of the Netherlands reviewed penicillamine. Penicillamine is used as a chelator in Wilson's disease, in copper, mercury and lead intoxications and can be prescribed in case of cystinuria and rheumatoid arthritis. This report is part of a series, in which the Health Council evaluates the effects of substances on reproduction, at request of the Minister of Social Affairs and Employment. It mainly concerns substances to which man can be exposed occupationally. The Subcommittee on the Classification of Reproduction Toxic Substances of the Dutch Expert Committee on Occupational Safety of the Health Council, hereafter called the Committee, evaluates the effects on male and female fertility and on the development of the progeny. Furthermore, the Committee considers the effects of a substance on lactation and on the progeny via lactation. The Committee recommends classification according to Regulation (EC) 1272/2008 of the European Union. For penicillamine, these recommendations are: • for effects on fertility, the Committee recommends not classifying penicillamine due to a lack of appropriate data • for effects on development, the Committee recommends classifying penicillamine in category 1B (presumed human reproductive toxicant) and labelling with H360D (may damage the unborn child) • for effects on or via lactation, the Committee recommends not labelling penicillamine due to a lack of appropriate data.

Project Status: Completed

Year Published: 2014

URL for published report: http://www.gr.nl/sites/default/files/201415_penicillamine_osh.pdf

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Netherlands

Organisation Name: Health Council of the Netherlands Gezondheidsraad

Contact Address: Postbus 16052, 2500 BB Den Haag, The Netherlands. Tel: +31 70 340 7520;Fax: +31 70 340 7523

Contact Name: info@gr.nl

Contact Email: info@gr.nl

Copyright: Health Council of the Netherlands