[Health technology assessment of low stimulation IVF compared with standard IVF]

Ingerslev HJ, Højgaard A, Poulsen PB, Kesmodel U, Dinesen J
Record ID 32002000045
Original Title: Medicinsk teknologivurdering af lavstimulations IVF sammenlignet med standard IVF
Authors' objectives: The aim of the present health technology assessment study was to compare the present routinely used protocol for ovarian hyperstimulation (GnRH-a + FSH, standard IVF = S-IVF) with "friendly IVF" using clomiphene citrate (CC-IVF).
Authors' recommendations: The results of the present HTA analysis showed a rather impressive acceptance among the infertile couples of treatment modalities with a lower overall efficiency than the presently used standard protocol balanced against avoidance of side effects and a more simple treatment procedure. The economic analysis supports such a concept by showing that the CC-IVF protocol was cost-effective compared to the S-IVF protocol when considering IVF-related hospital costs within and outside the clinic. This health technology assessment analysis therefore strongly suggests that clomiphene stimulation for IVF should be offered as a primary treatment protocol for infertile couples where the female is younger than 35 and where the cause of infertility is tubal, unexplained or due to severely impaired semen quality with indication for ICSI. This option is primarily the choice of the couples themselves being informed about the pros and cons of the two treatments.
Authors' methods: Overview
Project Status: Completed
Year Published: 2001
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Denmark
MeSH Terms
  • Fertilization in Vitro
  • Reproductive Techniques, Assisted
Organisation Name: Danish Centre for Evaluation and Health Technology Assessment
Contact Address: National Board of Health, PO Box 1881, Islands Brygge 67, DK-2300 Copenhagen S, Denmark. Tel: 45 72 22 74 48; Fax: 45 72 22 74 07/67
Contact Name: dacehta@sst.dk
Contact Email: dacehta@sst.dk
Copyright: Danish Centre for Evaluation and Health Technology Assessment (DACEHTA) (formerly DIHTA)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.