[Efficacy of intraoperative radiation therapy]

Dussault FP, Moqadem K
Record ID 32015000402
Original Title: Efficacité de la radiothérapie peropératoire
Authors' recommendations: The Direction québécoise de cancérologie (DQC) asked to INESSS to review the state of the evidence on IORT applied to breast, rectal and brain cancers because it wanted an update on the clinical usefulness of this technology before considering its potential deployment in Québec's health system. Breast cancer The available evidence leads to the conclusion that IORT should not become common practice in the current conditions unless rigorously monitored under institutional protocols, coupled with well-built follow-up registries. But, the outcomes of two large-scale randomized controlled trials using two different sources of radiation revealed the potential clinical effectiveness and safety of IORT as an adjuvant treatment after lumpectomy in patients with early-stage cancer. Rectal cancer The efficacy of IORT for rectal cancer has not been convincingly proven. Brain cancer The observation drawn from the still recent explorations in the update or search for the optimal conditions for using IORT systems applied to the brain confirms the need to conduct phase III trials, some of which are in the planning stages or ongoing.
Project Status: Completed
Year Published: 2015
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Canada
MeSH Terms
  • Radiotherapy
  • Combined Modality Therapy
  • Intraoperative Care
  • Breast Neoplasms
  • Brain Neoplasms
  • Rectal Neoplasms
  • Colorectal Neoplasms
  • Glioma
Organisation Name: Institut national d'excellence en sante et en services sociaux
Contact Address: L'Institut national d'excellence en sante et en services sociaux (INESSS) , 2021, avenue Union, bureau 10.083, Montreal, Quebec, Canada, H3A 2S9;Tel: 1+514-873-2563, Fax: 1+514-873-1369
Contact Name: demande@inesss.qc.ca
Contact Email: demande@inesss.qc.ca
Copyright: ©Gouvernement du Québec/Institut national d'excellence en santé et en services sociaux
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