[Low-dose computed tomography screening for lung cancer]

Sánchez González MC, Cantero Muñoz P, Atienza Merino G
Record ID 32015000397
Authors' objectives: To evaluate safety and effectiveness of the low-dose computed tomography (LDTC) for lung cancer screening in heavy smokers (individuals with smoking history of at least 20 pack years or former smokers with less than 10 years of abstinence). To estimate the performance of the screening (sensitivity, specificity, predictive positive value, false positives).
Authors' recommendations: The results of a high quality study favours LDCT over TxR, however, the screening with TxR is not a recommended nor a standard screening for lung cancer. The low statistical power and heterogeneity of the trials that compare LDCT to usual care difficult the assessment of differences in mortality rates. The high false positive rates, similar advanced cancer detected between screening rounds, overdiagnosis or costs are some of the concerns about LDCT screening. It would be necessary to assess the data from the only study with enough statistical power and sample size to detect differences in mortality with the usual care, whose results are expected in 2016.
Project Status: Completed
Year Published: 2016
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Spain
MeSH Terms
  • Humans
  • Lung Neoplasms
  • Tomography, X-Ray Computed
Organisation Name: Scientific Advice Unit, avalia-t; The Galician Health Knowledge Agency (ACIS)
Contact Address: Conselleria de Sanidade, Xunta de Galicia, San Lazaro s/n 15781 Santiago de Compostela, Spain. Tel: 34 981 541831; Fax: 34 981 542854;
Contact Name: avalia-t@sergas.es
Contact Email: avalia-t@sergas.es
Copyright: Galician Agency for Health Technology Assessment (AVALIA-T)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.