Tracleer (Bosentan; Actelion Pharmaceuticals Ltd.) for treatment of digital ulcers in patients with scleroderma
Record ID 32015000358
Authors' recomendations: The cause of scleroderma is not known but it is thought that scleroderma is an autoimmune disease that causes the skin and connective tissue to tighten and harden, which can lead to scarring, ulcers, and gastrointestinal disorders and that can affect major organs, such as the lung, heart, and kidneys, and the blood vessels. Digital ulcers manifest as part of the more serious form of scleroderma, called systemic sclerosis, occurring in 30% to 60% of patients. Digital ulcers are primarily caused by decreased blood flow to the digits, and possible thrombosis, but thickening and tightening of the skin of the fingers and toes (sclerodactyly), the formation of calcium deposits in soft tissue (calcinosis), and/or endothelial cell injury may also play a role in the development of digital ulcers. Digital ulcers can recur and are often extremely painful, slow to heal, result in scars and tissue loss, and become infected, which can lead to bone infection (osteomyelitis), gangrene, and amputation.
Project Status: Completed
Year Published: 2014
URL for published report: The report may be purchased from: http://www.hayesinc.com/hayes/crd/?crd=17170
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: United States
- Endothelin Receptor Antagonists
- Scleroderma, Systemic
- Dose-Response Relationship, Drug
- Treatment Outcome
- Antihypertensive Agents
- Hand Dermatoses
- Wound Healing
Organisation Name: HAYES, Inc.
Contact Address: 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218
Contact Name: email@example.com
Contact Email: firstname.lastname@example.org
Copyright: 2014 Winifred S. Hayes, Inc
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.