Authors' recommendations: The available evidence from the clinical trials indicates that sustained virological response (SVR) was achieved by more than 90% of patients who received sofosbuvir (SOF) and ledipasvir (LDV) with or without ribavirin (RBV) for 8, 12 or 24 weeks; SOF and daclatasvir (DCV) with or without RBV for 12 or 24 weeks; SOF and GS-9669 plus RBV for 12 weeks in treatment naïve and treatment experienced patients. Lower rates of SVR were reported in those who only received SOF plus RBV. Serious AEs and discontinuation due to AEs were low and anemia, rash and depression were low in patients who did not receive RBV. LDV, DCV and GS-9669 have not yet received Health Canada Notice of Compliance (NOC). Two economic evaluations conducted outside of Canada demonstrated that SOF plus simeprivir (SIM) is more cost-effective than SOF plus RBV. However, cost-effectiveness of SOF plus SIM in a Canadian population is uncertain.

Project Status: Completed

Year Published: 2014

URL for published report: http://www.cadth.ca/media/pdf/htis/jul-2014/RC0563%20IFN%20Free%20Regimens%20Final.pdf

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Canada

Organisation Name: Canadian Agency for Drugs and Technologies in Health

Contact Address: 600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553; Fax: +1 613 226 5392;

Contact Name: requests@cadth.ca

Contact Email: requests@cadth.ca

Copyright: Canadian Agency for Drugs and Technologies in Health (CADTH)