Authors' recommendations: Dietary weight loss interventions, either alone or in combination with exercise produced greater reductions in the peak knee compressive force and plasma levels of interleukin-6 (IL-6) in knee OA patients compared with exercise-induced weight loss. Significantly greater reduction in pain and improvements in functions were reported in patients who received diet plus exercise interventions compared with either dietonly or exerciseonly interventions. Regardless of group assignment, participants who lost 10% or more of baseline body weight had greater reductions in knee compressive force, systemic IL-6 concentrations, and pain, as well as gained greater improvement in function than those who lost less of their baseline weight. However, participants who lost the most weight also experienced greater loss of bone mass density at the femoral neck and hip, but not the spine, without a significant change of their baseline clinical classification with regards to osteoporosis or osteopenia. Findings from a cohort study suggest that patients with hip osteoarthritis could achieve weight loss associated with significant improvement in their physical function, mobility, and pain scores.

Project Status: Completed

Year Published: 2014

URL for published report: http://www.cadth.ca/media/pdf/htis/nov-2014/RC0564-003%20Obesity%20Interventions%20%20and%20%20Osteoarthritis%20Final.pdf

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Canada

Organisation Name: Canadian Agency for Drugs and Technologies in Health

Contact Address: 600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553; Fax: +1 613 226 5392;

Contact Name: requests@cadth.ca

Contact Email: requests@cadth.ca

Copyright: Canadian Agency for Drugs and Technologies in Health (CADTH)