Authors' recommendations: The ICURs of sofosbuvir versus appropriate comparators varied widely across genotypes and various subgroups. Analyses in genotype 1 patients were limited by lack of direct comparative data. Most of the analyses in genotype 2 and genotype 3 patients were limited by the small sample size of the clinical trials used to inform efficacy inputs. Based on CDR reanalyses, sofosbuvir is likely cost-effective in the following subgroups: genotype 1 treatment-naive cirrhotic patients (compared with boceprevir and Peg-INF/RBV, but analyses were based on very small subgroups, and on a naive indirect treatment comparison); genotype 2 Peg-INF/RBV-ineligible and prior-relapsers or breakthrough (except cirrhotic patients) compared with no treatment and Peg-INF/RBV; genotype 3 prior-relapsers or breakthrough with cirrhosis, compared with no treatment and Peg-INF/RBV.

Project Status: Completed

Year Published: 2014

URL for published report: http://www.cadth.ca/media/cdr/pharmacoeconomic/SR0356_Sovaldi_PE_Report_e.pdf

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Canada

Organisation Name: Canadian Agency for Drugs and Technologies in Health

Contact Address: 600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553; Fax: +1 613 226 5392;

Contact Name: requests@cadth.ca

Contact Email: requests@cadth.ca

Copyright: Canadian Agency for Drugs and Technologies in Health (CADTH)