[Systematic review of efficacy and economic impact of genetic tests in breast cancer and depression treatment]

Escalona-López S, Callejo-Velasco D, Blasco-Amaro JA
Record ID 32015000025
Spanish
Authors' recommendations: The level of evidence found is low due to the studies design, generally retrospective and heterogeneous with basal characteristics patients. There are needed more investigations to know better the balance benefit-risk with the use of genetic tests. It will be necessary to obtain the most direct evidence on clinical utility across the clinical trials TAILORx and MINDACT. In depression patients, studies are very heterogeneous and analyze different polymorphisms without uniform criteria. There would be needed studies that assess the most emphasized polymorphisms and with more influence in treatment response.
Details
Project Status: Completed
Year Published: 2010
URL for published report: http://www.madrid.org/cs/Satellite?blobcol=urldata&blobheader=application%2Fpdf&blobheadername1=Content-disposition&blobheadername2=cadena&blobheadervalue1=filename%3DRev.+sistem%C3%A1tica+sobre+eficacia+e+impacto+econ%C3%B3mico+de+pruebas+gen%C3%A9ticas+en+el+tratamiento+del+c%C3%A1ncer+de+mama+y+la+depresi%C3%B3n+UETS+09-04.pdf&blobheadervalue2=language%3Des%26site%3DPortalSalud&blobkey=id&blobtable=MungoBlobs&blobwhere=1352812946504&ssbinary=true
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Spain
MeSH Terms
  • Breast Neoplasms
  • Female
  • Depression
  • Depressive Disorder, Major
Contact
Organisation Name: Unidad de Evaluacion de Tecnologias Sanitarias
Contact Address: Elena Andradas Aragones, Unidad de Evaluacion de Tecnologias Sanitarias, Agencia Lain Entralgo, C/ Gran Via, 27, 8a, ES-28013 Madrid, Spain. Tel: +34 91 3089418; Fax: +34 91 3089458;
Contact Name: elena.andradas@salud.madrid.org
Contact Email: elena.andradas@salud.madrid.org
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.