Pharmacokinetic/pharmacodynamic measures for guiding antibiotic treatment for hospital acquired pneumonia
Lux LJ, Posey RE, Daniels LS, Henke DC, Durham C, Jonas DE, Lohr KN
Record ID 32014001422
English
Authors' objectives:
To conduct a systematic review of the use of pharmacokinetic/pharmacodynamic (PK/PD) measures or strategies to dose and monitor intravenous (IV) antibiotics in the treatment of adults with hospital-acquired pneumonia (HAP).
Authors' recommendations:
In the setting of increasing antimicrobial resistance worldwide and limited new antibiotics in the pipeline, optimizing dosing with PK/PD strategies could serve as an important antimicrobial stewardship tool to improve the use of currently available antibiotics. While PK/PD dosing strategies are supported by concept, the lack of prospective patient outcome data leaves clinicians with little guidance on how to best apply these principles to patient care. This review highlights the significant need for additional research to illuminate the role of antibiotic PK/PD dose optimization for the treatment of HAP.
Details
Project Status:
Completed
Year Published:
2014
URL for published report:
http://www.effectivehealthcare.ahrq.gov/ehc/products/522/2008/pneumonia-antibiotic-treatment-report-141124.pdf
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
United States
MeSH Terms
- Cross Infection
- Pneumonia
Contact
Organisation Name:
Agency for Healthcare Research and Quality
Contact Address:
Center for Outcomes and Evidence Technology Assessment Program, 540 Gaither Road, Rockville, MD 20850, USA. Tel: +1 301 427 1610; Fax: +1 301 427 1639;
Contact Name:
martin.erlichman@ahrq.hhs.gov
Contact Email:
martin.erlichman@ahrq.hhs.gov
Copyright:
Agency for Healthcare Research and Quality (AHRQ)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.