Vasodilators for inhospital heart failure management: a rapid review
Record ID 32014001032
Authors' objectives: The objective of this analysis was to determine the risk of adverse events associated with vasodilators used for inhospital management of heart failure. In particular, what is the effect on renal function and risk of mortality for patients administered intravenous nitroglycerin or nesiritide in hospital?
Authors' recommendations: No systematic reviews, meta-analyses, or health technology assessments on the safety and effectiveness of nitroglycerin or nesiritide were identified in the literature search. No RCTs were identified evaluating the safety of nitroglycerin. One large multicentre RCT addressed these questions with regard to nesiritide. No statistically significant increase in risk of mortality (GRADE: moderate) or renal dysfunction (GRADE: high) was found, compared to placebo.
Project Status: Completed
Year Published: 2013
URL for published report: http://www.hqontario.ca/Portals/0/Documents/eds/rapid-reviews/vasodilators-heart-failure-130117-en.pdf
English language abstract: An English language summary is available
Publication Type: Not Assigned
- Heart Failure
Organisation Name: Health Quality Ontario
Contact Address: Evidence Development and Standards, Health Quality Ontario, 130 Bloor Street West, 10th floor, Toronto, Ontario Canada M5S 1N5
Contact Name: EDSinfo@hqontario.ca
Contact Email: OH-HQO_htafirstname.lastname@example.org
Copyright: Health Quality Ontario
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