Vasodilators for inhospital heart failure management: a rapid review

Schaink A
Record ID 32014001032
Authors' objectives: The objective of this analysis was to determine the risk of adverse events associated with vasodilators used for inhospital management of heart failure. In particular, what is the effect on renal function and risk of mortality for patients administered intravenous nitroglycerin or nesiritide in hospital?
Authors' recommendations: No systematic reviews, meta-analyses, or health technology assessments on the safety and effectiveness of nitroglycerin or nesiritide were identified in the literature search. No RCTs were identified evaluating the safety of nitroglycerin. One large multicentre RCT addressed these questions with regard to nesiritide. No statistically significant increase in risk of mortality (GRADE: moderate) or renal dysfunction (GRADE: high) was found, compared to placebo.
Project Status: Completed
Year Published: 2013
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Canada
MeSH Terms
  • Heart Failure
  • Inpatients
  • Hospitalization
Organisation Name: Health Quality Ontario
Contact Address: Evidence Development and Standards, Health Quality Ontario, 130 Bloor Street West, 10th floor, Toronto, Ontario Canada M5S 1N5
Contact Name:
Contact Email:
Copyright: Health Quality Ontario
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.