[Efficacy, safety and efficiency of platelet rich plasma in the treatment of aseptic nonunion]
Vega-Coca MD, Giráldez-Sánchez MA, Márquez-Peláez S, Nieto-Rodríguez MR, Isabel-Gómez R, Beltrán-Calvo C
Record ID 32014001023
Spanish
Original Title:
Eficacia, seguridad y eficiencia del plasma rico en plaquetas en el tratamiento de la pseudoartrosis aséptica
Authors' objectives:
To assess the efficacy, safety and efficiency of PRP, administered alone or in combination with conventional surgery, in the treatment of aseptic nonunion.
Authors' recommendations:
The evidence found on the efficacy and safety of PRP in the treatment of aseptic nonunion is limited to low to medium quality case series and to the isolated results obtained for one of the arms of a randomized controlled trial. There is remarkable variability in terms of the population included, the surgical technique used and the method applied for the collection of PRP.
Despite the positive outcomes reported in most studies, there is no solid evidence that PRP (administered alone or as adjuvant treatment to conventional surgery) is effective in healing aseptic nonunion.
No serious complications have been associated with PRP in patients with aseptic nonunion. The reported complications are, in general terms, mild and self-limited. However, there is no evidence on the long-term safety of this technique.
Although promising results have been obtained in terms of efficacy and safety, the potential benefits of PRP reported in the studies identified in the systematic review should be confirmed through the performance of high methodological quality studies with a randomized controlled design.
As regards cost-effectiveness, there is no scientific evidence on the cost-effectiveness of using PRP for aseptic nonunion.
Details
Project Status:
Completed
Year Published:
2014
URL for published report:
https://www.aetsa.org/publicacion/eficacia-seguridad-y-eficiencia-del-plasma-rico-en-plaquetas-en-el-tratamiento-de-la-pseudoartrosis-aseptica/
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Spain
MeSH Terms
- Platelet-Rich Plasma
- Fracture Fixation
- Fractures, Ununited
Keywords
- Platelet-Rich Plasma
- Fractures ununited
Contact
Organisation Name:
Andalusian Health Technology Assessment Area
Contact Address:
Area de Evaluacion de Tecnologias Sanitarias Sanitarias de Andalucia (AETSA) Avda. Innovación, s/n Edificio Arena 1. Sevilla (Spain) Tel. +34 955 006 309
Contact Name:
aetsa.csalud@juntadeandalucia.es
Contact Email:
aetsa.csalud@juntadeandalucia.es
Copyright:
Andalusian Agency for Health Technology Assessment (AETSA)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.