Authors' objectives: An estimated 33,190 individuals in the United States will be diagnosed with primary liver cancer in 2014 and nearly 23,000 will die from the disease. Surgery can cure early disease but most patients present with unresectable disease or multiple liver metastases from other cancers. Colorectal cancer (CRC) is metastatic at diagnosis in 20% of patients and is the most common indication for hepatic resection and the most common etiology of metastases to liver. For patients with unresectable metastatic CRC, radiofrequency ablation (RFA) of hepatic metastases is associated with improved survival and quality of life. Locoregional hepatocellular carcinoma (HCC) and metastatic CRC are currently treated with thermal ablation with RFA and microwave ablation (MWA). These methods heat the tissue, causing denaturation of proteins. Thermal ablation methods heat the tissue, causing denaturation of proteins. The resultant zone of tissue destruction surrounding the intended target can damage normal liver tissue and nearby organs, hepatic ducts, and blood vessels, which leads to the need for alternative therapies.

Project Status: Completed

Year Published: 2014

URL for published report: The report may be purchased from: http://www.hayesinc.com/hayes/crd/?crd=16746

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: United States

Organisation Name: HAYES, Inc.

Contact Address: 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218

Contact Name: saleinfo@hayesinc.com

Contact Email: saleinfo@hayesinc.com

Copyright: 2014 Winifred S. Hayes, Inc