VeriStrat test to predict response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC)

Record ID 32014000969
Authors' objectives: It is estimated that, in 2014, more than 224,000 Americans will be diagnosed with lung cancer, and that more than 159,000 will die from the disease, making lung cancer the leading cause of cancerrelated deaths in the United States. Non-small cell lung cancer (NSCLC) accounts for more than 80% of lung cancers and includes squamous cell carcinomas, adenocarcinomas, and large cell carcinomas of the lung. In general, NSCLC responds poorly to standard chemotherapy and radiation treatment regimens, which is reflected in a 5-year survival rate of only 14%. Newer treatments for NSCLC include targeted therapies, which are medications that target specific proteins involved in tumor growth and progression, such as the epidermal growth factor receptor (EGFR). When activated, the tyrosine kinase receptor EGFR triggers downstream signaling cascades that play a role in the regulation of cell growth, proliferation, differentiation, and survival. Because of its involvement in signaling cascades known to play a role in a variety of malignancies (including lung cancer), EGFR has been an important target for the development of such medications. Several EGFR tyrosine kinase inhibitors (TKIs) have been developed and are designed to prevent the activation of EGFR, thereby inhibiting receptor tyrosine kinase activity and downstream signaling cascades. Erlotinib and gefitinib are EGFR TKIs used in NSCLC patients who have failed at least 1 prior chemotherapy regimen. However, the effectiveness of these medications appears to be limited to 10% to 30% of treated patients. This response rate has led to the search for predictive biomarkers to help identify patients who are more likely to benefit from these medications. Investigated biomarkers that may help predict EGFR TKI efficacy include the presence of EGFR gene variants, EGFR gene amplification, and the presence of Kirsten rat sarcoma viral oncogene (KRAS) sequence variants. More recently, the VeriStrat test was developed to identify patients most likely to respond to EGFR TKI therapy. The assay utilizes mass spectrometry, a technique that analyzes the mass-to-charge ratio of charged particles, to characterize the protein profile of pretreatment serum from NSCLC patients who are candidates for EGFR TKI therapy. A classification algorithm is then used to categorize patients according to the likelihood of treatment response.
Project Status: Completed
Year Published: 2014
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: United States
MeSH Terms
  • Lung Neoplasms
  • Neoplasm Staging
  • Protein Kinase Inhibitors
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Organisation Name: HAYES, Inc.
Contact Address: 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218
Contact Name:
Contact Email:
Copyright: 2014 Winifred S. Hayes, Inc
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