United Kingdom Oscillation Study: long-term outcomes of a randomised trial of two modes of neonatal ventilation
Greenough A, Peacock J, Zivanovic S, Alcazar-Paris M, Lo J, Marlow N, Calvert S.
Record ID 32014000723
English
Authors' objectives:
To compare respiratory and functional outcomes of school-age children born extremely
prematurely who received either high-frequency oscillation (HFO) or conventional ventilation (CV)
immediately after birth to test the hypothesis that the use of HFO would be associated with superior small
airway function at school age without adverse effects
Authors' recommendations:
Follow-up at 11–14 years of age of extremely prematurely born infants entered into a
randomised trial of HFO versus CV has demonstrated significant differences in lung function in favour of
HFO. There was no evidence that this was offset by poorer functional outcomes; indeed, HFO children did
better in some school subjects. It will be important to determine whether or not these differences are
maintained after puberty as this is the last positive effect on lung function.
Details
Project Status:
Completed
Year Published:
2014
URL for published report:
http://www.journalslibrary.nihr.ac.uk/hta/hta18410/#/abstract
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
England, United Kingdom
MeSH Terms
- Humans
- Infant, Newborn
- Respiration, Artificial
Contact
Organisation Name:
NIHR Health Technology Assessment programme
Contact Address:
NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name:
journals.library@nihr.ac.uk
Contact Email:
journals.library@nihr.ac.uk
Copyright:
Queen's Printer and Controller of HMSO
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.