Antiplatelet and anticoagulant treatments for unstable angina/non–ST elevation myocardial infarction
Melloni C, Jones WS, Washam JB, Hasselblad V, Mayer SB, Halim S, Subherwal S, Alexander K, Kong DF, Heidenfelder BL, Irvine RJ, Wing L, Dolor RJ
Record ID 32014000520
English
Authors' objectives:
For patients with unstable angina or non–ST elevation myocardial infarction (UA/NSTEMI), antiplatelet and anticoagulant medications are prescribed to reduce and prevent ischemic events and mortality. There is uncertainty about the optimal dosing and timing of these medications to balance ischemic risk and bleeding risk across different treatment strategies (early invasive, initial conservative, and postdischarge).
Authors' recommendations:
The number of studies available for each comparison was relatively small, and the preponderance of observational studies made the findings for some comparisons inconclusive. Further study is needed to determine the effectiveness and safety of newer agents in combination with other antiplatelet and anticoagulant strategies. Uncertainty remains about the optimal dosing, timing, duration, and combinations of these options, especially in subpopulations of interest (e.g., the elderly, patients with diabetes, women, obese patients, and people with comorbid illness).
Details
Project Status:
Completed
Year Published:
2014
URL for published report:
http://www.effectivehealthcare.ahrq.gov/ehc/products/374/1734/angina-heart-attack-treatments-report-140120.pdf.pdf
URL for additional information:
http://www.effectivehealthcare.ahrq.gov/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productID=1734
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
United States
MeSH Terms
- Humans
- Myocardial Infarction
- Angina, Unstable
- Platelet Aggregation Inhibitors
- Anticoagulants
Contact
Organisation Name:
Agency for Healthcare Research and Quality
Contact Address:
Center for Outcomes and Evidence Technology Assessment Program, 540 Gaither Road, Rockville, MD 20850, USA. Tel: +1 301 427 1610; Fax: +1 301 427 1639;
Contact Name:
martin.erlichman@ahrq.hhs.gov
Contact Email:
martin.erlichman@ahrq.hhs.gov
Copyright:
Agency for Healthcare Research and Quality (AHRQ)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.