Original Title: 비파열 뇌동맥류의 예방적 치료에 대한 성과연구

Authors' recommendations: Seven thousand four hundred and four patients with UIAs (unruptured intracranial aneurysm) were identified, including 1441 treated patients (20%) and 5963 untreated patients (80%), with a median follow-up of 3.3 years. Rupture events occurred in 163 (0.9 cases/100 person-years) of the 5963 untreated patients. The rupture rate was highest in the 1st year after the UIA diagnosis. Older age was a risk factor for rupture among patients with UIAs, with most of the precedent studies on preventative treatments focused on observational studies showing a lack of evidence. Of 4160 studies, 24 were identified (n = 31865). Clipping resulted in significantly higher disability using the Glasgow Outcome Scale (OR, 2.38; 95% CI, 1.33–4.26) and Modified Rankin Scale (OR, 2.83; 95% CI, 1.42–5.63) when compared with coiling. ORs for complications were also higher with clipping (ORs for neurological and cardiac complications were 1.94 with a 95% confidence interval [CI] of 1.09–3.47 and 2.51 with a 95% CI of 1.15–5.50). Clipping resulted in significantly greater disability in the short term (≤6 m) (OR on the Glasgow Outcome Scale, 2.72; 95% CI, 1.16–6.34), but not in the long term (>6 m) (OR for Glasgow Outcome Scale, 2.12; 95% CI, 0.93–4.84). For a natural history of unruptured cerebral aneurysms and proper treatment guidelines for the disease, we need data that consider the characteristics of cerebral aneurysms. The accumulation of study results based on national data is highly called for.

Project Status: Completed

Year Published: 2011

URL for published report: https://www.neca.re.kr/lay1/program/S1T11C145/report/view.do?seq=30

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: South Korea

Organisation Name: National Evidence-based healthcare Collaborating Agency

Contact Address: National Evidence-based Healthcare Collaborating Agency (NECA), 3~5F Health and Welfare Social Administration B/D, 400 Neungdong-ro, Gwangjin-gu, Seoul, Korea.

Contact Name: int@neca.re.kr

Contact Email: int@neca.re.kr

Copyright: National Evidence-based Healthcare Collaborating Agency (NECA)