[A study on the factors influencing adherence to antidepressant therapies and the cost-effectiveness of antidepressant therapies in Korea]

Ahn J, Jung SY, Shin S, Song HJ, Park JY, Back JW, Seo GH, Kim JY, Han CS, Woo JM, Lee MS, Kim NS, Kim KM, Kim CM, Jung SH
Record ID 32014000422
Original Title: 항우울제 투약순응도에 영향을 미치는 요인분석 및 경제성 평가
Authors' recommendations: Twenty-nine percent of patients (more than 75% MPR in 90 days from the index date) among patients who had been prescribed antidepressants for acute depression were adherents, and 34% of patients among the ones who had already previously been diagnosed with depression were adherent (more than 75% MPR in 180 days from the index date). These results were comparable to the ones reported in the international literature. As antidepressant adherence increases, the recurrence risk, defined as hospitalization in a psychiatry department, an emergency visit for depression, a suicide attempt, and the recommencement of antidepressant therapy 6 months after discontinuation, decreases. In addition, adherence was higher in patients who had received psychotherapies along with antidepressants. This result suggests that various attempts to promote psychotherapies along with antidepressants are necessary. From a cost-effectiveness analysis of the treatment paths, it seems SSRIs are the most cost-effective first-line antidepressant class of drugs unless patients have severe anxiety or insomnia, or have physical symptoms, in which case, NADs are more appropriate.
Project Status: Completed
Year Published: 2011
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: South Korea
MeSH Terms
  • Antidepressive Agents
  • Depressive Disorder, Major
  • Korea
Organisation Name: National Evidence-based healthcare Collaborating Agency
Contact Address: National Evidence-based Healthcare Collaborating Agency (NECA), 3~5F Health and Welfare Social Administration B/D, 400 Neungdong-ro, Gwangjin-gu, Seoul, Korea.
Contact Name: int@neca.re.kr
Contact Email: int@neca.re.kr
Copyright: National Evidence-based Healthcare Collaborating Agency (NECA)
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