Original Title: 급성 심근경색증 환자에서 약물방출 스텐트와 금속 스텐트의 비교

Authors' recommendations: In this meta-analysis of 52,503 patients with STEMI from forty-nine studies including RCTs and observational studies, the use of DES compared with BMS was associated with a significant reduction in TVR and TLR. DES and BMS did not show any differences in adverse effects such as death or stent thrombosis in RCTs. The use of DES in RCTs was associated with a statistically significant reduction in the recurrence of myocardial infarction, but the significance level was within the margin. In observational studies, the use of DES was associated with a significant reduction in mortality compared with BMS. However, there were no differences between DES and BMS in recurrent myocardial infarction and stent thrombosis overall. The use of DES was related to a significant increase in stent thrombosis compared with BMS in the observational studies with over two years of follow-up. However, caution is needed to interpret this result because it is derived from observational studies and the evidence level was evaluated as "very low quality". The use of DES appears to cost more than BMS. However, since this study was very sensitive to the costs and proportions of patients without revascularization, additional studies are required to obtain more accurate estimates of the costs and the proportions of patients without revascularization after initial stenting. Large-scale, long term local RCTs or prospective studies of high quality are required to ascertain the clinical efficacy, safety, and economic effects of DES compared with BMS.

Project Status: Completed

Year Published: 2010

URL for published report: https://www.neca.re.kr/lay1/program/S1T11C145/report/view.do?seq=27

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: South Korea

Organisation Name: National Evidence-based healthcare Collaborating Agency

Contact Address: National Evidence-based Healthcare Collaborating Agency (NECA), 3~5F Health and Welfare Social Administration B/D, 400 Neungdong-ro, Gwangjin-gu, Seoul, Korea.

Contact Name: int@neca.re.kr

Contact Email: int@neca.re.kr

Copyright: National Evidence-based Healthcare Collaborating Agency (NECA)