Epidural injection of enbrel (etanercept; Immunex Corp.) for treatment of low back pain due to lumbar disc disease
Record ID 32014000389
English
Authors' recommendations:
Low back pain (LBP) is a common ailment affecting up to 80% of all people at some point in their lifetime and approximately 28% of adults annually in the United States. The immune system protein (cytokine), tumor necrosis factor-alpha (TNF-) has been implicated in playing a role in LBP. TNF has been identified in human herniated lumbar disc tissue (including the nucleus pulposus, ligamentum flavum, posterior annulus, and the annulus fibrosus), and in adult lumbar degenerative disc tissue. TNF- is secreted by immune system cells as a reaction to a foreign substance. TNFacts as a messenger between immune system cells, calling them to action, which results in an inflammatory reaction, and which could contribute to LBP in patients with lumbar disc disease.
Details
Project Status:
Completed
Year Published:
2013
URL for published report:
The report may be purchased from: http://www.hayesinc.com/hayes/crd/?crd=16104
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
United States
MeSH Terms
- Humans
- Immunoglobulin G
- Immunosuppressive Agents
- Low Back Pain
- Lumbar Vertebrae
- Injections, Epidural
Contact
Organisation Name:
HAYES, Inc.
Contact Address:
157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218
Contact Name:
saleinfo@hayesinc.com
Contact Email:
saleinfo@hayesinc.com
Copyright:
2013 Winifred S. Hayes, Inc
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.