Immunoglobulin gene testing in b-cell lymphoma

Record ID 32014000381
English
Authors' recommendations: Lymphoma refers to a group of cancers of the lymphatic system, which includes lymph nodes, blood, and bone marrow. The World Health Organization (WHO) has classified > 40 types of lymphoma, with the 2 most common types being non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). In 2013, > 700,000 people were classified as affected with lymphoma or in remission. Of these, approximately 170,000 and 550,000 have HL and NHL, respectively, and median age at diagnosis of 64 years. Approximately 85% of NHL cases are B-cell lymphomas (BCL), which are further categorized based on clinical symptoms and histologic and morphologic criteria. However, in 5% to 15% of patients, these methods do not provide a definitive diagnosis. In these patients, evaluation of immunoglobulin (IG) genes may provide further information to aid in diagnosis. These genes are involved in B-cell development whereby a series of rearrangements occurs in IG genes, resulting in a large number of products of multiple sizes (referred to as polyclonality). In cancer, however, an error during recombination may result in a single rearrangement occurring multiple times, leading to the amplification of a single clone (referred to as clonality or monoclonality). Therefore, by analyzing specific regions of the IG genes immunoglobulin heavy locus (IGH) and immunoglobulin kappa locus (IGK), clonality or polyclonality may be evaluated to potentially provide information regarding malignancy, and provide supportive evidence for lymphoma diagnoses in combination with other criteria (which include clinical and histologic findings).
Details
Project Status: Completed
Year Published: 2013
URL for published report: The report may be purchased from: http://www.hayesinc.com/hayes/crd/?crd=15943
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: United States
MeSH Terms
  • Lymphoma, B-Cell
  • Genes, Immunoglobulin Heavy Chain
Contact
Organisation Name: HAYES, Inc.
Contact Address: 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218
Contact Name: saleinfo@hayesinc.com
Contact Email: saleinfo@hayesinc.com
Copyright: 2013 Winifred S. Hayes, Inc
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