[Intraoperative radiation therapy in the treatment of breast cancer]
Cantero-Muñoz P, Atienza Merino G
Record ID 32014000348
Spanish
Authors' objectives:
To assess the effectiveness of IORT as adjuvant or replacement treatment for the current standard treatment of breast cancer, in terms of recurrence, survival, cosmetic results and impact on quality of life; and to ascertain the safety of this procedure, in terms of acute and late toxicity.
Authors' recommendations:
The results of studies that assess IORT as an alternative to an external-radiation booster dose indicate that this combination does not amount to an increase in terms of effectiveness and overall survival, nor does it entail a significant reduction in terms of safety with respect to conventional external radiation treatment. These results are drawn from studies of little methodological rigour, and there are no clinical trials that would go to confirm them. Administration of a single dose of IORT is associated with an incidence of recurrences and metastasis comparable to that of conventional treatment, and, despite showing low toxicity, does not improve the toxicity of conventional treatment to any significant degree. This evidence is based on a single RCT with certain limitations and on observational and descriptive studies, something that considerably reduces the validity of these results. Indeed, the results of the studies included give rise to important doubts regarding the possible replacement of conventional external radiotherapy by intraoperative radiation as the treatment of choice in patients with breast cancer in the initial stages.
Details
Project Status:
Completed
Year Published:
2013
URL for published report:
http://www.sergas.es/Docs/Avalia-t/avaliat201214RioCaMama.pdf
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Spain
MeSH Terms
- Intraoperative Period
- Radiotherapy
Contact
Organisation Name:
Scientific Advice Unit, avalia-t; The Galician Health Knowledge Agency (ACIS)
Contact Address:
Conselleria de Sanidade, Xunta de Galicia, San Lazaro s/n 15781 Santiago de Compostela, Spain. Tel: 34 981 541831; Fax: 34 981 542854;
Contact Name:
avalia-t@sergas.es
Contact Email:
avalia-t@sergas.es
Copyright:
Galician Agency for Health Technology Assessment (AVALIA-T)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.