[eFlow® vibrating membrane nebulizer for the treatment of cystic fibrosis]

Pichon Riviere A, Augustovski F, Garcia Marti S, Glujovsky D, Alcaraz A, Lopez A, Bardach A, Ciapponi A
Record ID 32014000310
Authors' objectives: To assess the evidence available on the safety, efficacy and other issues related to the coverage polices of the use of eFlow® (vibrating membrane nebulizer) for the treatment of cystic fibrosis patients.
Authors' recommendations: The information included in this report comes from small, low methodological quality studies and most of them do not report relevant clinical results. The only advantage shown in the published studies is shorter nebulization time with eFlow® when compared with conventional devices. However, this does not show relevant clinical benefits beyond its potential better adherence. Also, one study mentions that its performance may decrease after 6 months in use. In addition, there are other nebulizers (e.g., I-neb®) with which it may be compared, since they have potential advantages. So far, based on the evidence found, there is no evidence that shows the clinical benefit of eFlow® over conventional devices beyond nebulization times. More properly designed studies are required to assess if eFlow® would have a relevant benefit in patients with cystic fibrosis.
Project Status: Completed
Year Published: 2012
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Argentina
MeSH Terms
  • Nebulizers and Vaporizers
  • Drug Delivery Systems
  • Cystic Fibrosis
Organisation Name: Institute for Clinical Effectiveness and Health Policy
Contact Address: Dr. Emilio Ravignani 2024, Buenos Aires - Argentina, C1414 CABA
Contact Name: info@iecs.org.ar
Contact Email: info@iecs.org.ar
Copyright: Institute for Clinical Effectiveness and Health Policy (IECS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.