[Catheter-directed mechanical thrombolysis in thromboembolic disease]

Pichon Riviere A, Augustovski F, Garcia Marti S, Glujovsky D, Alcaraz A, Lopez A, Bardach A, Ciapponi A
Record ID 32014000309
Authors' objectives: To assess the evidence available on the efficacy, safety, and issues related to the coverage policies of catheter-directed mechanical thrombolysis for the treatment of thromboembolic disease.
Authors' recommendations: The evidence found on the use of mechanical thrombolysis in DVT and PTE is of poor methodological quality since it comes from non controlled studies only. Despite the low quality of the evidence, clinical practice guidelines found recommend the use of mechanical thrombolysis in patients with massive PTE and contraindication for systemic thrombolysis. However, the health sponsors surveyed do not cover this technology. Caution should be exerted since these studies have multiple biases resulting from both design and patient screening and publication. As regards DVT and despite the evidence is also of poor quality, the guidelines suggest catheter-directed thrombolysis in selected patients with acute extensive and proximal DVT. Studies with other methodological designs are required to support the data presented in this document with more scientific evidence.
Project Status: Completed
Year Published: 2012
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Argentina
MeSH Terms
  • Humans
  • Thrombolytic Therapy
Organisation Name: Institute for Clinical Effectiveness and Health Policy
Contact Address: Dr. Emilio Ravignani 2024, Buenos Aires - Argentina, C1414 CABA
Contact Name: info@iecs.org.ar
Contact Email: info@iecs.org.ar
Copyright: Institute for Clinical Effectiveness and Health Policy (IECS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.