[Combined screening for early diagnosis of chromosomal abnormalities during the first trimester of pregnancy]

Pichon Riviere A, Augustovski F, Garcia Marti S, Glujovsky D, Alcaraz A, Lopez A, Bardach A, Ciapponi A, Valanzasca P
Record ID 32014000296
Authors' objectives: To assess the available evidence on the efficacy, safety and coverage related issues about the use of combined screening for early diagnosed chromosomal abnormalities during the first trimester of pregnancy.
Authors' recommendations: The evidence reported in this document comes from studies of good methodological quality and statistical power. Combined screening in the first trimester has a Down syndrome detection rates ranging from 85% to 94%, with false positive rates under 5%. The clinical practice guidelines consulted suggest counselling to all pregnant women on the existence of these screening tests, regardless of their maternal age. These guidelines recommend this screening be performed at specialized centers with specific training and standardize quality controls.
Project Status: Completed
Year Published: 2012
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Argentina
MeSH Terms
  • Humans
  • Pregnancy
  • Pregnancy Trimester, First
  • Mass Screening
  • Prenatal Diagnosis
  • Chromosome Aberrations
Organisation Name: Institute for Clinical Effectiveness and Health Policy
Contact Address: Dr. Emilio Ravignani 2024, Buenos Aires - Argentina, C1414 CABA
Contact Name: info@iecs.org.ar
Contact Email: info@iecs.org.ar
Copyright: Institute for Clinical Effectiveness and Health Policy (IECS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.