[Photodynamic therapy for head and neck cancer treatment]

Pichon Riviere A, Augustovski F, Garcia Marti S, Glujovsky D, Alcaraz A, Lopez A, Bardach A, Ciapponi A, Gonzalez L
Record ID 32014000287
Authors' objectives: To assess the available evidence on the efficacy, safety and coverage policy related aspects on the use of Photodynamic Therapy for the treatment of head and neck cancer.
Authors' recommendations: The evidence found was of poor quality, comprising some RCTs with methodological defects and several uncontrolled case series. The main limitation to evaluate the usefulness of PDT for head and neck cancer is the lack of comparative studies against the standard treatment options. The patients included in the studies found are a heterogeneous group of cases; they included patients with oral, nasal, pharynx cavity, hypopharynx and larynx lesions at different stages; some of them are primary lesions and others are recurrent or refractory to different types of treatments. If compared directly, some of the results could be similar to those achieved with other therapeutic methods such as surgery or radiotherapy where the initial local control rates reported range between 50% and 95%. In other cases, the results reported seem to be better, when comparing those patients undergoing surgery or rescue radiotherapy, with overall survival rates achieved at 12 months around 50%. However, it is worth mentioning that direct comparison with standard options is not possible in view of the heterogeneity of the populations in the PDT studies. Although the method has a lower morbidity than the other alternatives, to date there is no evidence to recommend PDT use as a therapeutic alternative for the treatment of head and neck cancer.
Project Status: Completed
Year Published: 2012
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Argentina
MeSH Terms
  • Photochemotherapy
Organisation Name: Institute for Clinical Effectiveness and Health Policy
Contact Address: Dr. Emilio Ravignani 2024, Buenos Aires - Argentina, C1414 CABA
Contact Name: info@iecs.org.ar
Contact Email: info@iecs.org.ar
Copyright: Institute for Clinical Effectiveness and Health Policy (IECS)
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