[Risk-reducing surgery in BRCA1 or 2 mutation carriers]
Pichon Riviere A, Augustovski F, Garcia Marti S, Alcaraz A, Glujovsky D, Lopez A, Rey-Ares L, Bardach A, Ciapponi A, Gonzalez L
Record ID 32014000247
Spanish
Authors' objectives:
To assess the available evidence on the efficacy, safety and coverage related aspect regarding the use of risk-reducing surgery in BRCA1/2 mutation female carriers.
Authors' recommendations:
The quality of the evidence found is poor. RRBM and RRSO as risk-reducing strategies showed a decrease in the incidence of cancer in deleterious mutation female carriers, although only in the case of RRSO, this benefit was associated with a lower mortality. Even though the evidence is still poor and low quality, there is an international consensus to recommend RRSO, specially in women under 40, and in considering and discussing in detail the risks and benefits of RRBM. Since the individual risk may differ among carriers, as well as the benefit expected from the different therapeutic strategies, a genetic consultation is considered key to the decision making process
Details
Project Status:
Completed
Year Published:
2013
URL for published report:
https://www.iecs.org.ar/home-ets/?cod_publicacion=1559&familia=5&origen_publicacion=buscador
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Argentina
MeSH Terms
- BRCA1 Protein
- BRCA2 Protein
- Risk Reduction Behavior
- Surgical Procedures, Operative
Contact
Organisation Name:
Institute for Clinical Effectiveness and Health Policy
Contact Address:
Dr. Emilio Ravignani 2024, Buenos Aires - Argentina, C1414 CABA
Contact Name:
info@iecs.org.ar
Contact Email:
info@iecs.org.ar
Copyright:
Institute for Clinical Effectiveness and Health Policy (IECS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.