Authors' objectives: To assess the available evidence on the efficacy, safety and coverage policy related aspects on the use of preimplantation genetic screening in patients undergoing assisted reproduction technologies.

Authors' recommendations: The available evidence is of good methodological quality, although still heterogeneous and not describing all the relevant outcomes. Also, some study findings (especially with FISH at Day 3) are contradictory. Those studies that made use of the new technologies and assessed all the chromosomes agree that the rates of implantation might increase when using PGS. However, it should be considered that the rate per cycle and the impact on quality of life that a potential reduction in time to pregnancy, rate of live births with chromosomal abnormalities and rates of abortion may have, were not assessed. This technology should be assessed for each method used, whether FISH, aCGH, qPCR or any other, as well as for the time biopsy is performed (Day 3 or blastocyst) and for the number of chromosomes assessed; also consideration should be given to cost-effectiveness and budget impact information. With the information published to date on each of the options, there is still limited information to allow assessing the potential benefit of this technology.

Project Status: Completed

Year Published: 2013

URL for published report: https://www.iecs.org.ar/home-ets/?cod_publicacion=1777&origen_publicacion=publicaciones

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Argentina

Organisation Name: Institute for Clinical Effectiveness and Health Policy

Contact Address: Dr. Emilio Ravignani 2024, Buenos Aires - Argentina, C1414 CABA

Contact Name: info@iecs.org.ar

Contact Email: info@iecs.org.ar

Copyright: Institute for Clinical Effectiveness and Health Policy (IECS)