Probiotics for antibiotic-associated diarrhea, <i>clostridium difficile</i> infection and irritable bowel syndrome: a review of clinical evidence and safety
CADTH
Record ID 32014000229
English
Authors' recommendations:
A large body of evidence from meta-analyses and randomized controlled trials indicate that compared with placebo, probiotics may reduce the incidence of antibiotic-associated diarrhea and may reduce the severity of symptoms related to irritable bowel syndrome. However, significant heterogeneity and low quality trials require conduct of further well-designed randomized trials that directly compare probiotics. Limited evidence from one meta-analysis suggests treatment with Saccharomyces boulardii in addition to vancomycin or metronidazole may reduce the incidence of recurrent C. difficile infection versus antibiotics alone.
Details
Project Status:
Completed
Year Published:
2013
URL for published report:
http://www.cadth.ca/media/pdf/htis/jan-2013/RC0420%20Probiotics%20Final.pdf
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Canada
MeSH Terms
- Diarrhea
- Clostridioides difficile
- Clostridium Infections
- Irritable Bowel Syndrome
Contact
Organisation Name:
Canadian Agency for Drugs and Technologies in Health
Contact Address:
600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553; Fax: +1 613 226 5392;
Contact Name:
requests@cadth.ca
Contact Email:
requests@cadth.ca
Copyright:
Canadian Agency for Drugs and Technologies in Health (CADTH)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.