Transcatheter aortic valve replacement in severe aortic stenosis: a review of comparative durability and clinical effectiveness beyond 12 months
Record ID 32014000189
Authors' recomendations: In follow-up longer than 12 months, findings support the use of TAVR as an alternative to conventional surgery in selected high-risk patients with aortic stenosis, with similar clinical outcomes such as mortality and re-hospitalization rates, neurologic events, and myocardial infarction. Major vascular complications and neurologic events were more frequent with TAVR. The two methods, TAVR and SAVR, had similar echocardiographic hemodynamic findings. Compared with standard treatment, TAVR was superior with regards to long term clinical outcomes and improved symptoms. A meta-analysis of larger trials with sensitivity analyses on study design, sample size, baseline characteristics, and surgeons experience is needed to reconfirm the findings.
Project Status: Completed
Year Published: 2013
URL for published report: http://www.cadth.ca/media/pdf/RD0029_TAVR_e.pdf
English language abstract: An English language summary is available
Publication Type: Not Assigned
- Aortic Valve Stenosis
- Heart Valve Prosthesis Implantation
Organisation Name: Canadian Agency for Drugs and Technologies in Health
Contact Address: 600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553; Fax: +1 613 226 5392;
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Copyright: Canadian Agency for Drugs and Technologies in Health (CADTH)
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