What is the clinical effectiveness and cost-effectiveness of cytisine compared with varenicline for smoking cessation? A systematic review and economic evaluation

Leaviss J, Sullivan W, Ren S, Everson-Hock E, Stevenson M, Stevens J, Strong M, Cantrell A
Record ID 32013001086
Authors' objectives: The assessment will address the questions: What is the clinical and cost effectiveness of cytisine compared with varenicline for smoking cessation? Specifically, the assessment will: i) Review evidence on the effectiveness and safety of Cytisine in smoking cessation compared with Varenicline; ii) Develop an economic model to estimate the cost effectiveness of Cytisine in the context of NHS smoking cessation services; and iii) provide recommendations based on value of information analyses as to whether a head to head trial of cytisine and varenicline would represent effective use of resources. The NIHR HTA Programme commissioned this technology assessment report on behalf of the HTA Programme Director.
Authors' recommendations: On the basis of the evidence included in this review, varenicline and cytisine are both effective interventions to aid smoking cessation when compared with placebo. Cytisine is estimated to be both more clinically effective and cost-effective than varenicline. However, there is uncertainty in the decision, and a head-to-head trial of cytisine and varenicline would appear to be an effective use of resources.
Project Status: Completed
Year Published: 2014
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England, United Kingdom
MeSH Terms
  • Alkaloids
  • Azocines
  • Quinolizines
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name: journals.library@nihr.ac.uk
Contact Email: journals.library@nihr.ac.uk
Copyright: 2014 Queen's Printer and Controller of HMSO
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.