Allopurinol for chronic kidney disease: a systematic review

Fleeman N, Pilkington G, Dundar Y, Dwan K, Boland A, Dickson R, et al.
Record ID 32013001083
English
Authors' objectives: The aim of this review is to consider the clinical effectiveness of allopurinol for people with CKD. Primarily, the review will consider the evidence in terms of effects on mortality, progression of CKD and effects on cardiovascular risk. The effects on mortality will be measured by all-cause deaths. Progression of CKD will be measured by the proportion of deaths attributable to CKD, patients requiring dialysis and/or transplantation and change in eGFR levels. Cardiovascular risk will be measured by the proportion of patients dying due to cardiovascular disease, experiencing cardiovascular events and with cardiovascular risk factors (see Table 3 for more detail about these events and risk factors). In addition to the primary outcomes, evidence will be sought for the effects on disease markers (levels of uric acid, serum creatinine and albuminuria, number of patients with endothelial dysfunction and/or left ventricular hypertrophy), number of blood pressure medications, AEs and quality of life. If the data allow, subgroups based on stage of CKD, age, gender, ethnicity and co-morbidities will also be considered. Based on the evidence from the systematic review, recommendations for future practice and/or research will be made. The NIHR HTA Programme commissioned this technology assessment report on behalf of the HTA Programme Director.
Details
Project Status: Completed
URL for project: https://www.journalslibrary.nihr.ac.uk/programmes/hta/124501/#/
Year Published: 2014
URL for published report: https://www.journalslibrary.nihr.ac.uk/hta/hta18400#/abstract
Requestor: NIHR Health Technology Assessment programme
English language abstract: An English language summary is available
Publication Type: Full HTA
Country: England, United Kingdom
DOI: https://doi.org/10.3310/hta18400
MeSH Terms
  • Allopurinol
  • Hyperuricemia
  • Renal Insufficiency, Chronic
Contact
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name: journals.library@nihr.ac.uk
Contact Email: journals.library@nihr.ac.uk
Copyright: Queen's Printer and Controller of HMSO
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.