[Efficacy, safety and efficiency of computed tomographic colonography vs. colonoscopy as colorectal cancer screening test]

Martín-López JE, Márquez-Peláez S, Adam-Blanco D, Navarro-Caballero JA, Rodríguez-López R, Beltrán-Calvo C
Record ID 32013001036
Authors' objectives: To assess CT colonography accuracy, security and efficiency in comparison to colonoscopy for CRC screening.
Authors' recommendations: CT colonography pooled sensitivity for CRC screening was lower than for colonoscopy, both per lesion or per patient analysis. Only in a specific subgroup with polyps between 8 and 10 mm and according to analysis per lesion CT colonography showed higher pooled sensibility than colonoscopy. The pooled specificity of CT colonography was higher than that colonoscopy according to analysis per patient, but not in analysis per lesion. .Accuracy get higher according to lesion size with maximum for lesions >10 mm. Adverse effects incidence for CT colonography and colonoscopy was low. None study analyzed the long-term side effects derived from the total CT colonography radiation emitted. Interpretation of these results could be limited by bias risk detected in included studies (lack of blinding or adequate gold standard). The evidence for CTC efficiency in comparison to no screen was favourable for CTC screening, however, in comparison to others screening tests (FOBT and colonoscopy) varied in terms of cost/utility and cost/effectivity. Studies with direct comparisons were needed in our environment.
Project Status: Completed
Year Published: 2013
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Spain
MeSH Terms
  • Colonography, Computed Tomographic
  • Colonoscopy
  • Mass Screening
Organisation Name: Andalusian Health Technology Assessment Area
Contact Address: Area de Evaluacion de Tecnologias Sanitarias Sanitarias de Andalucia (AETSA) Avda. Innovación, s/n Edificio Arena 1. Sevilla (Spain) Tel. +34 955 006 309
Contact Name: aetsa.csalud@juntadeandalucia.es
Contact Email: aetsa.csalud@juntadeandalucia.es
Copyright: Andalusian Agency for Health Technology Assessment (AETSA)
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