Treatment for hepatitis C virus infection in adults

Chou R, Hartung D, Rahman B, Wasson N, Cottrell E, Fu R
Record ID 32013000770
Authors' objectives: This report systematically reviews the comparative benefits and harms of current antiviral treatment regimens for chronic hepatitis C virus (HCV) infection in treatment-naïve adults.
Authors' recommendations: Although there is no direct evidence on the comparative effects of current antiviral regimens on long-term clinical outcomes, SVR rates are substantially higher in patients with HCV genotype 1 infection who receive triple therapy with pegylated interferon (alfa-2a or alfa-2b), ribavirin, and boceprevir or telaprevir compared with dual therapy with pegylated interferon plus ribavirin. Achieving an SVR following antiviral therapy appears to be associated with decreased risk of all-cause mortality compared with no SVR, although estimates are susceptible to residual confounding.
Project Status: Completed
Year Published: 2012
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: United States
MeSH Terms
  • Humans
  • Hepatitis C
Organisation Name: Agency for Healthcare Research and Quality
Contact Address: Center for Outcomes and Evidence Technology Assessment Program, 540 Gaither Road, Rockville, MD 20850, USA. Tel: +1 301 427 1610; Fax: +1 301 427 1639;
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Contact Email:
Copyright: Agency for Healthcare Research and Quality (AHRQ)
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