The ankle brachial index for peripheral artery disease screening and cardiovascular disease prediction in asymptomatic adults: a systematic evidence review for the U.S. Preventive Services Task Force

Lin JS, Olson CM, Johnson ES, Senger CA, Soh CB, Whitlock EP
Record ID 32013000755
Authors' objectives: We conducted a systematic evidence review on the diagnostic and prognostic value of the resting ankle-brachial index (ABI) in unselected populations. This review also examined the benefit and harms of treating generally asymptomatic persons with peripheral artery disease (PAD). We conducted this review to support the U.S. Preventive Services Task Force in updating its recommendation on screening for PAD.
Authors' recommendations: There is very limited evidence examining the diagnostic accuracy of the ABI as a screening tool (one study) or examining the treatment of generally asymptomatic persons with PAD or a low ABI (two trials). However, there is a large body of evidence (18 population-based cohorts) suggesting that a low ABI is independently associated with increased CAD and CVD risk, after adjusting for FRS factors. Despite this association, the magnitude of risk reclassification of ABI in addition to FRS is still unclear and is likely small. The net reclassification may have the largest impact among persons age 65 years and older and persons at the thresholds of FRS risk categories.
Project Status: Completed
Year Published: 2013
URL for additional information:
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: United States
MeSH Terms
  • Peripheral Arterial Disease
  • Cardiovascular Diseases
Organisation Name: Agency for Healthcare Research and Quality
Contact Address: Center for Outcomes and Evidence Technology Assessment Program, 540 Gaither Road, Rockville, MD 20850, USA. Tel: +1 301 427 1610; Fax: +1 301 427 1639;
Contact Name:
Contact Email:
Copyright: Agency for Healthcare Research and Quality (AHRQ)
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