[Cytoreductive surgery and intraperitoneal chemotherapy (HIPEC or EPIC) in patients with colorectal adenocarcinoma and peritoneal carcinomatosis.]

Ludwigs K, Breimer ME, Brorson F, Carlsson G, Daxberg E-L, Hjalmarsson Y, Skullman S, Strandell A, JivegÄrd L
Record ID 32013000623
Authors' objectives: Does cytoreductive surgery (CRS) combined with intraperitoneal chemotherapy (HIPEC or EPIC) for colorectal adenocarcinoma with peritoneal carcinosis result in improved survival, longer progression free survival, improved health related quality of life and fewer complications and side effects compared to systemic chemotherapy?
Authors' recomendations: There is moderate quality of evidence for prolonged survival (22.4 versus 12.6 months) by CRS+HIPEC versus systemic chemotherapy in patients with colo-rectal cancer and isolated peritoneal carcinosis. The effects on health related quality of life are unknown. The prolonged survival by CRS+HIPEC is observed mainly in those patients where complete cytoreduction is obtained denoting the importance of patient selection and the quality of the surgery. CRS+HIPEC is associated with high morbidity, significant mortality and high costs.
Project Status: Completed
Year Published: 2013
English language abstract: An English language summary is available
Publication Type: Not Assigned
MeSH Terms
  • Adenocarcinoma
  • Carcinoma
  • Peritoneal Neoplasms
  • Chemotherapy, Adjuvant
  • Colorectal Neoplasms
  • Peritoneum
Organisation Name: The Regional Health Technology Assessment Centre
Contact Address: The Regional Health Technology Assessment Centre, Region Vastra Gotaland, HTA-centrum, Roda Straket 8, Sahlgrenska Universitetssjukhuset, 413 45 GOTHENBORG, Sweden
Contact Name: hta-centrum@vgregion.se
Contact Email: hta-centrum@vgregion.se
Copyright: The Regional Health Technology Assessment Centre (HTA-centrum), Region Vastra Gotaland
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