[Cytoreductive surgery with intraperitoneal chemotherapy for pseudomyxoma peritonei]

Brorson F, Breimer ME, Carlsson G, Daxberg E-L,Hjalmarsson Y, JivegÄrd L, Ludwigs K, Skullman S, Strandell A
Record ID 32013000622
Authors' objectives: Does complete cytoreductive surgery with intraperitoneal chemotherapy improve survival and quality of life in patients with pseudomyxoma peritonei (PMP) compared to debulking surgery with or without systemic chemotherapy?
Authors' recomendations: Pseudomyxoma peritonei is a rare disease. Thus, it is unlikely that adequately sized studies, evaluating treatment effects on survival, will be conducted. High long-term survival has been reported in selected cases. However, patients having had CRS+HIPEC have not been compared to adequate controls. Since PMP is a very rare disease, it is unlikely that controlled trials with an adequate sample size will be performed. There is no indication that quality of life is negatively affected by CRS+HIPEC. The method is expensive, and is associated with a high risk of serious complications. It is uncertain whether treatment with CRS+HIPEC/EPIC increases survival or affects quality of life in comparison to debulking surgery. Very low quality of evidence
Project Status: Completed
Year Published: 2013
English language abstract: An English language summary is available
Publication Type: Not Assigned
MeSH Terms
  • Chemotherapy, Adjuvant
  • Peritoneal Cavity
  • Combined Modality Therapy
Organisation Name: The Regional Health Technology Assessment Centre
Contact Address: The Regional Health Technology Assessment Centre, Region Vastra Gotaland, HTA-centrum, Roda Straket 8, Sahlgrenska Universitetssjukhuset, 413 45 GOTHENBORG, Sweden
Contact Name: hta-centrum@vgregion.se
Contact Email: hta-centrum@vgregion.se
Copyright: The Regional Health Technology Assessment Centre (HTA-centrum), Region Vastra Gotaland
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