[Cytoreductive surgery with intraperitoneal chemotherapy for pseudomyxoma peritonei]
Brorson F, Breimer ME, Carlsson G, Daxberg E-L,Hjalmarsson Y, Jivegård L, Ludwigs K, Skullman S,
Strandell A
Record ID 32013000622
Swedish
Authors' objectives:
Does complete cytoreductive surgery with intraperitoneal chemotherapy improve survival and quality of life in patients with pseudomyxoma peritonei (PMP) compared to debulking surgery with or without systemic chemotherapy?
Authors' recommendations:
Pseudomyxoma peritonei is a rare disease. Thus, it is unlikely that adequately sized studies, evaluating treatment effects on survival, will be conducted. High long-term survival has been reported in selected cases. However, patients having had CRS+HIPEC have not been compared to adequate controls. Since PMP is a very rare disease, it is unlikely that controlled trials with an adequate sample size will be performed. There is no indication that quality of life is negatively affected by CRS+HIPEC. The method is expensive, and is associated with a high risk of serious complications.
It is uncertain whether treatment with CRS+HIPEC/EPIC increases survival or affects quality of life in comparison to debulking surgery. Very low quality of evidence
Details
Project Status:
Completed
Year Published:
2013
URL for published report:
http://www.sahlgrenska.se/upload/SU/HTA-centrum/HTA-rapporter/Pseudomyxoma%20peritonei%20%E2%80%93-%20Behandling%20med%20cytoreduktiv%20kirurgi%20och%20intraperitoneal%20cytostatika%20inkl%20bil%202013-04-08.%202%20pdf.pdf
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
MeSH Terms
- Chemotherapy, Adjuvant
- Peritoneal Cavity
- Combined Modality Therapy
Contact
Organisation Name:
The Regional Health Technology Assessment Centre
Contact Address:
The Regional Health Technology Assessment Centre, Region Vastra Gotaland, HTA-centrum, Roda Straket 8, Sahlgrenska Universitetssjukhuset, 413 45 GOTHENBORG, Sweden
Contact Name:
hta-centrum@vgregion.se
Contact Email:
hta-centrum@vgregion.se
Copyright:
The Regional Health Technology Assessment Centre (HTA-centrum), Region Vastra Gotaland
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